Recent Publications

Chemical screening reveals small molecules reducing polyQ mediated toxicity caused by toxic CAG RNA in Huntington Disease (HD) and spinocerebellar ataxia (SCAs), 2018 (submitted)

E. Khan, S. K. Mishra, R. Mishra, A. Mishra, and Amit Kumar

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Restoration of miRNA-149 expression by TmPyP4 induced unfolding of quadruplex within its precursor. ACS Biochemistry,2018

Ghosh A, Ekka MK, Tawani A, Amit Kumar, Chakraborty D, Maiti S.

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Analytical techniques for characterization of biological molecules, Bioanalysis, 2018 (In Press)

H. Kaur, S. Bhagwat, T. K. Sharma, and Amit Kumar

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Piperine modulates RNA and protein gain of function toxicity in FXTAS through interacting with expanded r(CGG)exp repeat RNA, 2018 (Submitted)

A. K. Verma, E. Khan, S. K. Mishra and Amit Kumar

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The conserved G-quadruplex forming sequences found in L and G gene of Nipah virus possesses to be a novel anti-viral drug target, 2018 (Submitted)

P. Majee#, S. K. Mishra#, N. Pandya, U. Shankar, D. Nayak, and Amit Kumar

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Crystal structures of pyrrolidone-carboxylate peptidase I from Deinococcus radiodurans reveal the mechanism of L-pyroglutamate recognition, Acta Crystallographica Section D STRUCTURAL BIOLOGY, 2019 (In Press)

R. Agrawal, R. Singh, A. Kumar, Amit Kumar and R. D. Makde.

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G-quadruplex stabilization in the ions and maltose transporters inhibit Salmonella enterica growth and virulence, 2018 (Submitted)

N. Jain#, S. K. Mishra#, U. Shankar, A. Tawani, T. K. Sharma and Amit Kumar

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Targeting G-quadruplex structures in virus genome and its associated host factors could hold potential for antiviral drug discovery, 2018 (Submitted)

P. Majee, Amit Kumar* and D. Nayak*.

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Myricetin-Assisted Proteasomal Degradation Suppresses Misfolded Proteins Aggregation and Cytotoxicity, 2018 (Submitted)

V. Joshi, R. Mishra, A. Upadhyay, A. Amanullah, Amit Kumar, A. Mishra

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Rational truncation of aptamer for cross-species application to detect kraitenvenomation, Scientific Reports, 2018

Dhiman, A., Anand, A., Malhotra,A., Khan, E., Santra, V., Kumar, A., Sharma, T.K.

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The highly conserved G-Quadruplex motif in the phase variation system that controls Streptococcus pneumoniae virulence, Scientific Reports, 2018 (In Press)

S. K. Mishra, U. Shankar, N. Jain, A. Tawani, T. K. Sharma, Amit Kumar*

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Ni+2 permease system of Helicobacter pylori contains a highly conserved G-Quadruplex motif as a potential drug target, 2018 (Submitted)

Shankar, U., Mishra, S.K., Jain, N., Tawani, A., and Kumar, A.*

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Selection, characterization and optimization of a G-quadruplex DNA aptamer with potent inhibitory activity against malate synthase of Mycobacterium tuberculosis, 2018 (Submitted)

Dhiman, A.; Kumar, C.; Mishra S.K.; Amit Kumar; Sharma, T. K; Tyagi J. S.

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Rationally designed small molecules targeting toxic CAG repeat RNA that causes Huntington's Disease (HD) and Spinocerebellar ataxia (SCAs), 2018 (Submitted)

E. Khan, S. Biswas, S. K. Mishra, R. Verma, S. Samanta, A. Mishra, Amit Kumar*

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Structural switching electrochemical DNA aptasensor for the rapid diagnosis of tuberculous meningitis, International Journal of Nanomedicine, 2018 (In Press)

Das, R.; Dhiman, A.; Mishra, S. K.; Haldar S.; Sharma, N.; Bansal, A.; Ahmad., Y.; Amit Kumar; Sharma, T. K; Tyagi J. S.

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G-quadruplex motifs in genes encoding ESX-1 virulence factors EspB and EspK inhibit the survival of Mycobacterium tuberculosis, 2018 (Submitted)

S. K. Mishra, U. Shankar, N. Jain, A. Tawani, K. Sikri, J. S. Tyagi, T. K. Sharma, J.-L. Mergny, Amit Kumar*

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G-quadruplex forming DNA aptamers inhibit DNA-binding function of HupB (Rv2986c) and Mycobacterium tuberculosis entry into host cells, Molecular Therapy Nucleic Acids, 2018.

Kalra, P, Mishra S K.; Kaur S.; Prasad, H, P.; Amit Kumar ; Sharma, T. K; Tyagi J. S.

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Generation and application of DNA aptamers against HspX for accurate diagnosis of Tuberculous meningitis, Tuberculosis, 2018

A. Dhiman, K. Tripathi, S. Haldar, S. K. Mishra, N. Sharma, A. Bansal, A. S. Ethayathulla, Y. Ahmad, Amit Kumar , T. K. Sharma, J. S. Tyagi

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Aptamers in the therapeutics and diagnostics pipelines, Theranostics, 2018

H. Kaur, J.G. Bruno, Amit Kumar, T.K. Sharma

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Proteolysis to Identify Protease Substrates: Cleave to Decipher, Proteomics, 2018.

S.R. Bhagwat, K. Hajela Amit Kumar

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Multifunctional Inosine Monophosphate Coordinated Metal-Organic Hydrogel: Multi-stimuli Responsiveness, Self-healing Properties and Separation of Water from Organic Solvents, ACS Sustainable Chemistry & Engineering, 2018.

N. Thakur, B. Sharma, S. Bishnoi, S.K. Mishra, D. Nayak, Amit Kumar, T.K. Sarma

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SMMDB: Database for small molecule modulators as therapeutics in neurological diseases, Database, 2018.

S. K. Mishra, N. Jain, U. Shankar, A. Tawani, A. Mishra , Amit Kumar*

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Myricetin targeting CAG repeat RNA ameliorates pathophysiology of Huntington’s disease (HD) and Spino Cerebellar Ataxias (SCAs), ACS Chemical Biology, 2018.

Khan E.#; Tawani, A.#; Mishra, K. S.#; Verma, A.; Upadhyay, A.; Kumar, M.; Sandhir, R.; Mishra, A.; Kumar, Amit*

# Equal contribution

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Gp78 E3 Ubiquitin Ligase: Essential Functions and Contributions In Proteostasis, Frontiers in Cellular Neuroscience, 2017.

V. Joshi, A. Upadhyay, Amit Kumar and A. Mishra

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Structural insight for the recognition of G-quadruplex structure at human c-myc promoter sequence by flavonoid Quercetin, Scientific Reports, 2017.

A. Tawani, S. K. Mishra, Amit Kumar*

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Emerging Methods for Structural Analysis of Protein Aggregation, Protein and Peptide Letters, 2017.

E. Khan, S. K. Mishra, Amit Kumar*

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Lanosterol Suppresses The Aggregation And Cytotoxicity of Misfolded Proteins Linked with Neurodegenerative Diseases, Molecular Neurobiology, 2017. - Cover Page Story

A. Upadhyay, A. Amanullah, R. Mishra, Amit Kumar , A. Mishra

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Evidences for Piperine inhibiting cancer by targeting human G-quadruplex DNA sequences, Scientific Reports, 2016.

Arpita Tawani, Ayeman Amanullah, Amit Mishra and Amit Kumar*

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G4IPDB: A database for G-quadruplex structure forming nucleic acid interacting proteins, Scientific Reports, 2016.

Subodh Kumar Mishra, Arpita Tawani, Amit Mishra and Amit Kumar*

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A Decade of boon or burden: what has the CHIP ever done for cellular protein quality control mechanism implicated in Neurodegeneration and Aging?, Frontiers in Molecular Neurosciences, 2016.

Vibhuti Joshi, Ayeman Amanullah, Arun Upadhyay, Ribhav Mishra, Amit Kumar and Amit Mishra

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NALDB: Nucleic Acid Ligand Database for small molecules targeting nucleic acid, Oxford Database, 2016.

Subodh Kumar Mishra, Amit Kumar*

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Structural Insight into the interaction of Flavonoids with Human Telomeric Sequence, Scientific Reports, 2016.

Arpita Tawani, Amit Kumar*

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Structural Insights Reveal the Dynamics of the Repeating r(CAG) Transcript Found in Huntington's Disease (HD) and Spinocerebellar Ataxias (SCAs), PLOS One, 2015.

Arpita Tawani, Amit Kumar*

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Lomofungin and dilomofungin: inhibitors of MBNL1-CUG RNA binding with distinct cellular effects, Nucleic Acid Research, 2013.

Hoskins JW, Ofori L,Chen CZ, Amit Kumar ,Sobczak K,Nakamori M,Southall N,Patnaik S,Marugan J, Zheng W, Austin CP, Disney MD, Miller BL, and Thornton CA.

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Design of a Bioactive Small Molecule That Targets the Myotonic Dystrophy Type 1 RNA via an RNA Motif-Ligand Database and Chemical Similarity Searching, Journal of American Chemical Society, 2012.

Parkesh R, Childs-Disney JL, Nakamori M, Amit Kumar , Wang E, Wang T, Hoskins J, Tran T, Housman D, Thornton CA, and Disney MD.

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Chemical correction of pre-mRNA splicing defects associated with sequestration of muscleblind-like 1 protein by expanded r(CAG)-containing transcripts, ACS Chemical Biology, 2012.

Amit Kumar , Parkesh R, Sznajder LJ, Childs-Disney JL, Sobczak K, Disney MD.

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A Crystal Structure of a Model of the Repeating r(CGG) Transcript Found in Fragile X Syndrome, ChemBioChem, 2011.

Amit Kumar , Fang P, Park H, Guo M, Nettles KW, Disney MD.

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Assessment of Genetic Diversity in Valeriana jatamansi Jones. Germplasm Using RAPD Markers, National Academy Science Letters, 2011.

Amit Kumar* , Shirkot P, Thakur AK, Raina R

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Myotonic dystrophy type 1 RNA crystal structures reveal heterogeneous 1X1 nucleotide UU internal loop conformations, Biochemistry, 2011.

Amit Kumar , Park H, Fang P, Parkesh R, Guo M, Nettles KW, Disney MD.

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Dr. Amit Kumar,
SB-216, BSBE, SCHOOL BUILDING
INDIAN INSTITUTE OF TECHNOLOGY INDORE
SIMROL CAMPUS, Khandwa road, INDORE,
Madhya Pradesh 453 552 INDIA

Telephone: +91-731-2438-771

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